A New Perspective on Scale-Down Strategies for Freezing of Biopharmaceutics by Means of Computational Fluid Dynamics
JOURNAL OF PHARMACEUTICAL SCIENCES, 109, 1978-1989 6 2020
Vitor Geraldes , Diana C. Gomes , Pedro Rego , Deborah Fegley , Miguel Rodrigues

Freezing of Biologicals Revisited: Scale, Stability, Excipients, and Degradation Stresses
JOURNAL OF PHARMACEUTICAL SCIENCES, 109, 44-61 1 2020
Jean-Rene Authelin , Miguel Rodrigues , Serguei Tchessalov , Satish K. Singh , Timothy McCoy , Stuart Wang , Evgenyi Shalaev

Stability of Protein Formulations at Subzero Temperatures by Isochoric Cooling
JOURNAL OF PHARMACEUTICAL SCIENCES, 109, 316-322 1 2020
Cátia Correia , Evandro Tavares , Carlos Lopes , Joana G. Silva , Andreia Duarte , Vitor Geraldes , Miguel Rodrigues , Eduardo P. Melo

Centrifugal nanofiltration for small-volume samples
JOURNAL OF MEMBRANE SCIENCE, 540, 411-421 10 2017
Carlos Completo , Vitor Geraldes , Viriato Semiao , Marilia Mateus , Miguel Rodrigues

Connecting high-temperature and low-temperature protein stability and aggregation
PLOS ONE, 12, 5 2017
Monica Rosa , Christopher J. Roberts , Miguel Rodrigues

Polymorphism in Pharmaceutical Drugs by Supercritical CO2 Processing: Clarifying the Role of the Antisolvent Effect and Atomization Enhancement
CRYSTAL GROWTH \& DESIGN, 16, 6222-6229 11 2016
Miguel Rodrigues , Joao M. Tiago , Andreia Duarte , Vitor Geraldes , Henrique A. Matos , Edmundo Azevedo

Improving Heat Transfer at the Bottom of Vials for Consistent Freeze Drying with Unidirectional Structured Ice
AAPS PHARMSCITECH, 17, 1049-1059 10 2016
Monica Rosa , Joao M. Tiago , Satish K. Singh , Vitor Geraldes , Miguel Rodrigues

Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents
CRYSTAL GROWTH \& DESIGN, 15, 3175-3181 7 2015
Luis Padrela , Miguel Rodrigues , Joao Tiago , Sitaram P. Velaga , Henrique A. Matos , Edmundo Azevedo

Enhancement of mass transfer in spacer-filled channels under laminar regime by pulsatile flow
CHEMICAL ENGINEERING SCIENCE, 123, 536-541 2 2015
Carina Rodrigues , Miguel Rodrigues , Viriato Semiao , Vitor Geraldes

New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride
PHARMACEUTICAL RESEARCH, 31, 3136-3149 11 2014
Miguel Rodrigues , Joao M. Tiago , Luis Padrela , Henrique A. Matos , Teresa G. Nunes , Lidia Pinheiro , Antonio J. Almeida , Edmundo Azevedo

Tuning physicochemical properties of theophylline by cocrystallization using the supercritical fluid enhanced atomization technique
JOURNAL OF SUPERCRITICAL FLUIDS, 86, 129-136 2 2014
Luis Padrela , Miguel Rodrigues , Joao Tiago , Sitaram P. Velaga , Henrique A. Matos , Edmundo Azevedo

Single-Step Co-Crystallization and Lipid Dispersion by Supercritical Enhanced Atomization
CRYSTAL GROWTH \& DESIGN, 13, 4940-4947 11 2013
Joao M. Tiago , Luis Padrela , Miguel Rodrigues , Henrique A. Matos , Antonio J. Almeida , Edmundo Azevedo

The Importance of Heat Flow Direction for Reproducible and Homogeneous Freezing of Bulk Protein Solutions
BIOTECHNOLOGY PROGRESS, 29, 1212-1221 9 2013
Miguel Rodrigues , Gustavo Balzan , Monica Rosa , Diana Gomes , Edmundo Azevedo , Satish K. Singh , Henrique A. Matos , Vitor Geraldes

Measuring and Modeling Hemoglobin Aggregation below the Freezing Temperature
JOURNAL OF PHYSICAL CHEMISTRY B, 117, 8939-8946 8 2013
Monica Rosa , Carlos Lopes , Eduardo P. Melo , Satish K. Singh , Vitor Geraldes , Miguel Rodrigues

Frozen-state storage stability of a monoclonal antibody: Aggregation is impacted by freezing rate and solute distribution
JOURNAL OF PHARMACEUTICAL SCIENCES, 102, 1194-1208 4 2013
Maria A. Miller , Miguel Rodrigues , Matthew A. Glass , Satish K. Singh , Keith P. Johnston , Jennifer A. Maynard

Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 82, 392-400 10 2012
Miguel Rodrigues , Lara Figueiredo , Luis Padrela , Ana Cadete , Joao Tiago , Henrique A. Matos , Edmundo Azevedo , Helena F. Florindo , Lidia Goncalves , Antonio J. Almeida

Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and In Vivo bioavailability
JOURNAL OF PHARMACEUTICAL SCIENCES, 101, 3763-3778 10 2012
Maria A. Miller , Tarik A. Khan , Kevin J. Kaczorowski , Brian K. Wilson , Aileen K. Dinin , Ameya U. Borwankar , Miguel Rodrigues , Thomas M. Truskett , Keith P. Johnston , Jennifer A. Maynard

Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions
JOURNAL OF SUPERCRITICAL FLUIDS, 58, 303-312 9 2011
Miguel Rodrigues , Luis Padrela , Vitor Geraldes , Jose Santos , Henrique A. Matos , Edmundo Azevedo

Effect of Freezing Rate and Dendritic Ice Formation on Concentration Profiles of Proteins Frozen in Cylindrical Vessels
JOURNAL OF PHARMACEUTICAL SCIENCES, 100, 1316-1329 4 2011
Miguel Rodrigues , Maria A. Miller , Matt A. Glass , Satish K. Singh , Keith P. Johnston

Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process
JOURNAL OF SUPERCRITICAL FLUIDS, 53, 156-164 6 2010
Luis Padrela , Miguel Rodrigues , Sitaram P. Velaga , Anabela Fernandes , Henrique A. Matos , Edmundo Azevedo